Search results for "Mechanistic model"
showing 10 items of 10 documents
Semi-Mechanistic Model for the Antitumor Response of a Combination Cocktail of Immuno-Modulators in Non-Inflamed (Cold) Tumors.
2021
Simple Summary The clinical efficacy of immunotherapies when treating cold tumors is still low, and different treatment combinations are needed when dealing with this challenging scenario. In this work, a middle-out strategy was followed to develop a model describing the antitumor efficacy of different immune-modulator combinations, including an antigen, a toll-like receptor-3 agonist, and an immune checkpoint inhibitor in mice treated with non-inflamed tumor cells. Our results support that clinical response requires antigen-presenting cell activation and also relies on the amount of CD8 T cells and tumor resistance mechanisms present. This mathematical model is a very useful platform to ev…
Mechanistic bioenergetics models to link functional traits to population dynamics: a study case with a marine bivalve
2013
Analysing and modelling the effect of nitrogen competition in weed regulation.
2020
Reducing the use of herbicide and mineral fertilizers is crucial to develop sustainable cropping systems. Such changes might result in an increased weed flora as well as intensify competition for resources, particularly nitrogen, between crops and weeds. The aim of this thesis was to analyze and model (via the mechanistic crop model FLORSYS) the key processes underlying nitrogen competition, in order to determine if changes in nitrogen fertilization techniques and cultivar choice could promote biological weed regulation.At the beginning of the thesis, the FLORSYS model (which simulates the effects of cropping systems in interaction with pedoclimate on weed dynamics) only included light comp…
The impact of climate change on Mediterranean intertidal communities: losses in coastal ecosystem integrity and services
2014
As has been shown for other ecosystems, the ecological and socio-economic impacts of climate change on Mediterranean intertidal habitats are highly variable in space and time. We conducted field and laboratory measurements of cellular, ecophysiological and behavioural responses of selected intertidal invertebrates (mussels, gastropods and sponges) and completed a literature review to determine what is known of socioeconomic consequences of these biological changes. Results suggest significant gaps in our knowledge that may impede a complete understanding of likely impacts (physical, biological, and socioeconomic) and that sufficient data for such an analysis is available only for mussels. A…
Parameterisation of bivalve functional traits for mechanistic eco-physiological dynamic energy budget (DEB) models
2013
Mechanistic models such as those based on dynamic energy budget (DEB) theory are emergent ecomechanics tools to investigate the extent of fitness in organisms through changes in life history traits as explained by bioenergetic principles. The rapid growth in interest around this approach originates from the mechanistic characteristics of DEB, which are based on a number of rules dictating the use of mass and energy flow through organisms. One apparent bottleneck in DEB applications comes from the estimations of DEB parameters which are based on mathematical and statistical methods (covariation method). The parameterisation process begins with the knowledge of some functional traits of a tar…
The role and management of crop-weed interactions in agroecological cropping systems
2020
International audience
Modélisation des effets des systèmes de culture sur la dynamique de la plante parasite orobanche rameuse en interaction avec les adventices
2019
Reducing pesticide use is a major challenge in agriculture and involves developing more sustainable methods that rely on non-chemical cropping techniques and biological regulations according to agroecological principles. Branched broomrape (Phelipanche ramosa (L.) Pomel) is a root parasitic plant which infects crops and causes dramatic yield losses worldwide. Managing broomrape is complex because it requires combining several cropping techniques whithin a global weed management strategy because broomrape is also able to infect non-parasitic weeds. The aim of this thesis was to stynthetize knowledge on branched broomrape dynamics in agroecosystems and to aggregate it within a mechanistic mod…
Modélisation des effets des systèmes de culture sur la dynamique de la plante parasite orobanche rameuse en interaction avec les adventices
2019
Reducing pesticide use is a major challenge in agriculture and involves developing more sustainable methods that rely on non-chemical cropping techniques and biological regulations according to agroecological principles. Branched broomrape (Phelipanche ramosa (L.) Pomel) is a root parasitic plant which infects crops and causes dramatic yield losses worldwide. Managing broomrape is complex because it requires combining several cropping techniques whithin a global weed management strategy because broomrape is also able to infect non-parasitic weeds. The aim of this thesis was to stynthetize knowledge on branched broomrape dynamics in agroecosystems and to aggregate it within a mechanistic mod…
Analysis and modeling of the role of nitrogen competition in weed control
2020
This project challenges the question of reducing herbicide use, considering that a concomitant reduction of nitrogen fertiliser use and a better choice of the sown species/varieties can help to design more sustainable cropping systems. Combining plant ecophysiology, ecology, agronomy and modelling, this project aims at analysing to which extent optimizing nitrogen fertilisation and crop species/cultivar choice can provide new ways to promote biological weed regulation via plant-plant competition, thereby reducing herbicide use. This project will use an original approach consisting in feeding and then using a mechanistic model, FLORSYS, predicting cropweed community assembly as a function of…
Modélisation des effets des systèmes de culture sur la dynamique de la plante parasite orobanche rameuse en interaction avec les adventices
2019
Reducing pesticide use is a major challenge in agriculture and involves developing more sustainable methods that rely on non-chemical cropping techniques and biological regulations according to agroecological principles. Branched broomrape (Phelipanche ramosa (L.) Pomel) is a root parasitic plant which infects crops and causes dramatic yield losses worldwide. Managing broomrape is complex because it requires combining several cropping techniques whithin a global weed management strategy because broomrape is also able to infect non-parasitic weeds. The aim of this thesis was to stynthetize knowledge on branched broomrape dynamics in agroecosystems and to aggregate it within a mechanistic mod…